Author

M. T. Naik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2

Frequent Co-Authors

N. L. Fawzi· 3 shared T. M. Perdikari· 2 shared V. H. Ryan· 2 shared A. A. Seyhan· 1 shared A. C. Hart· 1 shared A. C. Murthy· 1 shared A. Navaraj· 1 shared B. M. Rubenstein· 1 shared

Activity by Year

2020-2020 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

N. L. Fawzi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

J. Newton, G. Y. Li, M. T. Naik, N. L. Fawzi, J. M. Sedivy, G. Jogl

This paper shows that the N-terminus and coiled-coil domain of ORF1 protein mediate phase separation, which may protect L1 transcripts from degradation.

bioRxiv · Oct 29, 2020Biophysics

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

L. Zhou, K. Huntington, S. Zhang, L. Carlsen, E.-Y. So, C. Parker, I. Sahin, H. Safran, S. Kamle, C.-M. Lee, C.-G. Lee, J. A. Elias, K. S. Campbell, M. T. Naik, W. J. Atwood, , W. El-Deiry

This study shows MEK inhibitors reduce ACE2 and inflammatory cytokines, enhance NK cell activity, and block SARS-CoV-2 pseudovirus infection in human cells.

bioRxiv · Aug 2, 2020 · PreprintCell Biology

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins

T. M. Perdikari, A. C. Murthy, V. H. Ryan, S. Watters, M. T. Naik, N. L. Fawzi

This study shows SARS-CoV-2 nucleocapsid protein undergoes RNA-stimulated liquid-liquid phase separation, forming condensates with host RNA-binding proteins, which may aid viral genome packaging and host protein co-option.

bioRxiv · Jun 9, 2020Biochemistry

Predicting the Viability of Beta-Lactamase: How Folding and Binding Free Energies Correlate with Beta-Lactamase Fitness

J. Yang, N. Naik, J. S. Patel, C. S. Wylie, W. Gu, J. Huang, F. M. Ytreberg, M. T. Naik, D. M. Weinreich, B. M. Rubenstein

This paper evaluates how well thermodynamic folding and binding free energies predict the fitness of beta-lactamase mutants using experimental data and computational models.

bioRxiv · Apr 15, 2020Biophysics

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration

V. H. Ryan, T. M. Perdikari, M. T. Naik, C. F. Saueressig, J. Lins, G. L. Dignon, J. Mittal, A. C. Hart, N. L. Fawzi

The paper shows tyrosine phosphorylation of hnRNPA2 reduces granule component partitioning and neurodegeneration in a C. elegans model.

bioRxiv · Mar 15, 2020Biochemistry