Author

C. Scharnagl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Goetz· 2 shared B. Luy· 2 shared C. Muhle-Goll· 2 shared D. Langosch· 2 shared M. Silber· 2 shared A. Götz· 1 shared A. Vogel· 1 shared D. Huster· 1 shared

Activity by Year

2018-2018 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiophysics

A. Goetz

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

A. Goetz, N. Mylonas, P. Hoegel, M. Silber, H. Heinel, S. Menig, A. Vogel, H. Freyrer, D. Huster, B. Luy, D. Langosch, C. Scharnagl, C. Muhle-Goll, F. Kamp, H. Steiner

The paper shows that altering the flexibility of a di-glycine hinge in the APP transmembrane domain affects γ-secretase cleavage and specificity.

bioRxiv · Nov 20, 2018Biophysics

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP

A. Götz, P. Högel, M. Silber, I. Chaitoglou, B. Luy, C. Muhle-Goll, C. Scharnagl, D. Langosch

This study examines how the I45T mutation in APP affects H-bond stability and ε-cleavage efficiency, leading to altered Aβ levels in familial Alzheimer’s disease.

bioRxiv · Aug 4, 2018Biophysics

Dissecting Conformational Changes in APP’s Transmembrane Domain Linked to ε-Efficiency in Familial Alzheimer’s Disease

A. Goetz, C. Scharnagl

This study uses molecular dynamics simulations to analyze how FAD mutations in APP's TMD affect a-secretase cleavage efficiency by altering local and global structural dynamics.

bioRxiv · Feb 22, 2018Biophysics