Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP
A. Götz, P. Högel, M. Silber, I. Chaitoglou, B. Luy, C. Muhle-Goll, C. Scharnagl, D. Langosch
This study examines how the I45T mutation in APP affects H-bond stability and ε-cleavage efficiency, leading to altered Aβ levels in familial Alzheimer’s disease.
bioRxiv · Aug 4, 2018Biophysics