Author

D. Langosch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Luy· 2 shared C. Muhle-Goll· 2 shared C. Scharnagl· 2 shared M. Silber· 2 shared A. Goetz· 1 shared A. Götz· 1 shared A. Lorenzoni· 1 shared A. Vogel· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersBiophysics

B. Luy

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3 papers

Recent·Most cited

The metastable XBP1u transmembrane domain defines determinants for intramembrane proteolysis by signal peptide peptidase

S. S. Yucel, W. Stelzer, A. Lorenzoni, M. Wozny, D. Langosch, M. K. Lemberg

The paper identifies a transmembrane domain in XBP1u that mediates ER membrane insertion and shows that SPP-catalyzed proteolysis depends on TM helix dynamics and side chain interactions.

bioRxiv · Jan 29, 2019Cell Biology

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

A. Goetz, N. Mylonas, P. Hoegel, M. Silber, H. Heinel, S. Menig, A. Vogel, H. Freyrer, D. Huster, B. Luy, D. Langosch, C. Scharnagl, C. Muhle-Goll, F. Kamp, H. Steiner

The paper shows that altering the flexibility of a di-glycine hinge in the APP transmembrane domain affects γ-secretase cleavage and specificity.

bioRxiv · Nov 20, 2018Biophysics

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP

A. Götz, P. Högel, M. Silber, I. Chaitoglou, B. Luy, C. Muhle-Goll, C. Scharnagl, D. Langosch

This study examines how the I45T mutation in APP affects H-bond stability and ε-cleavage efficiency, leading to altered Aβ levels in familial Alzheimer’s disease.

bioRxiv · Aug 4, 2018Biophysics