The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy
Y. Mohamud, Y. Chao Xue, H. Liu, C. Seng Ng, A. Bahreyni, E. Jan, H. Luo
This study identifies SARS-CoV-2 papain-like protease (PLpro) as a novel substrate of ULK1, demonstrating its role in disrupting host autophagy to promote viral replication.
bioRxiv · Oct 23, 2020Cell Biology