Targeting integrin alpha5 receptor in pancreatic stellate cells to diminish tumor-promoting effects in pancreatic cancer
P. Kuninty, R. Bansal, S. De Geus, J. Schnittert, J. van Baarlen, G. Storm, M. Bijlsma, H. van Laarhoven, P. Kuppen, A. Vahrmeijer, A. Ostman, C. Sier, J. Prakash
This study shows that targeting ITGA5 in pancreatic stellate cells reduces tumor fibrosis and enhances chemotherapy efficacy in pancreatic cancer.
bioRxiv · Jun 19, 2018 · PreprintCancer Biology