Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo
S. Samer, Y. Thomas, M. Arainga, C. Carter, L. M. Shirreff, M. S. Arif, J. M. Avitia, I. Frank, M. D. McRaven, C. T. Thuruthiyil, V. B. Heybeli, M. R. Anderson, B. Owen, A. Gaisin, D. Bose, , E. Marinelli
This study shows that blocking TGF-β signaling increases HIV-1 and SIV reactivation and boosts immune responses in infected individuals on ART.
bioRxiv · May 13, 2022Immunology