Author

I. Frank

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2

Frequent Co-Authors

L. A. Vella· 3 shared A. E. Baxter· 2 shared A. Gettie· 2 shared A. Naji· 2 shared A. Pattekar· 2 shared B. Grasperge· 2 shared C. Cicala· 2 shared D. A. Oldridge· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

L. A. Vella

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection

L. B. Giron, Q. Liu, O. S. Adeniji, X. Yin, T. Kannan, J. Ding, D. Y. Lu, S. Langan, J. Zhang, J. L. L. C. Azevedo, S. H. Li, S. Shalygin, P. Azadi, D. B. Hanna, I. Ofotokun, , M. A. Mohsen

This study identifies glycomic alterations in HIV-positive individuals that correlate with accelerated aging and comorbidities, suggesting potential biomarkers for early detection.

bioRxiv · Aug 9, 2023 · PreprintMicrobiology

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo

S. Samer, Y. Thomas, M. Arainga, C. Carter, L. M. Shirreff, M. S. Arif, J. M. Avitia, I. Frank, M. D. McRaven, C. T. Thuruthiyil, V. B. Heybeli, M. R. Anderson, B. Owen, A. Gaisin, D. Bose, , E. Marinelli

This study shows that blocking TGF-β signaling increases HIV-1 and SIV reactivation and boosts immune responses in infected individuals on ART.

bioRxiv · May 13, 2022Immunology

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

R. R. Goel, M. M. Painter, S. A. Apostolidis, D. Mathew, W. Meng, A. M. Rosenfeld, K. A. Lundgreen, A. Reynaldi, D. S. Khoury, A. Pattekar, S. Gouma, L. Kuri-Cervantes, P. Hicks, S. Dysinger, A. Hicks, , Set

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

bioRxiv · Aug 23, 2021 · PreprintImmunology

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

bioRxiv · May 1, 2021Immunology

The identity of human tissue-emigrant CD8+ T cells

M. Buggert, L. A. Vella, S. Nguyen, V. Wu, T. Sekine, A. Perez-Potti, C. R. Maldini, S. Manne, S. Darko, A. Ransier, L. Kuri-Cervantes, A. Sada Japp, I. Bukh Brody, M. A. Ivarsson, L. Hertwig, , M. R. Betts

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

bioRxiv · Aug 11, 2020Immunology

Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection

M. Aravantinou, O. Mizenina, T. Brill, J. Kenney, C. Timmons, I. Frank, A. Gettie, B. Grasperge, J. Blanchard, A. Salazar, J. D. Lifson, M. Robbiani, N. Derby

This study investigates how HSV-2 and polyICLC immune stimulation affects SIV vaccine efficacy in rhesus macaques, finding that mucosal immune activation can enhance control of viremia in breakthrough infections.

bioRxiv · Jun 2, 2020 · PreprintImmunology

Mapping the lineage relationship between CXCR5+ and CXCR5- CD4+ T cells in HIV infected human lymph nodes

D. del Alcazar, Y. Wang, C. He, B. S. Wendel, P. M. Del Rio-Estrada, J. Lin, Y. Ablanedo-Terrazas, M. J. Malone, S. M. Hernande, I. Frank, A. Naji, G. Reyes-Teran, N. Jiang, L. F. Su

The paper identifies a CXCR5-negative CD4+ T cell subset in HIV-infected lymph nodes that shares lineage and functional traits with CXCR5+ T follicular helper cells.

bioRxiv · Jan 31, 2019Immunology

Protection of rhesus macaques against vaginal SHIV challenges by VRC01 and an anti-α4β7 antibody

G. Calenda, I. Frank, G. Arrode-Bruses, A. Pegu, K. Wang, J. Arthos, C. Cicala, B. Grasperge, J. L. Blanchard, S. Maldonado, K. Roberts, A. Gettie, A. S. Fauci, J. R. Mascola, E. Martinelli

This study shows that combining VRC01 and Rh-4β7 antibodies delays SHIV infection, preserves CD4+ T cells, and alters immune responses in macaques.

bioRxiv · Dec 11, 2018 · PreprintImmunology