C. T. Trinh

Consolidated Bioprocessing of Lignocellulosic Biomass Poplar to Produce Short-Chain Esters by Clostridium thermocellum

Probing Specificities of Alcohol Acyltransferases for Designer Ester Biosynthesis with a High-Throughput Microbial Screening Platform

This paper develops a high-throughput microbial screening platform to identify AATs for selective designer ester biosynthesis, demonstrating its effectiveness with specific AAT variants.

Endogenous esterases of Clostridium thermocellum are identified and disrupted for enhanced isobutyl acetate production from cellulose

This study identifies and disrupts endogenous esterases in Clostridium thermocellum to enhance isobutyl acetate production from cellulose by reducing ester hydrolysis.

Understanding and eliminating the detrimental effect of endogenous thiamine auxotrophy on metabolism of the oleaginous yeast Yarrowia lipolytica

This study identifies the genetic basis of thiamine auxotrophy in Yarrowia lipolytica and engineers a thiamine-prototrophic strain with enhanced lipid production.

Multiobjective Strain Design: A Framework for Modular Cell Engineering

This study introduces ModCell2, a framework for modular cell engineering that optimizes genetic modifications to balance modularity, performance, and robustness in production strains.

Exceptional Solvent Tolerance in Yarrowia lipolytica Is Enhanced by Sterols

This study engineered Yarrowia lipolytica to tolerate high concentrations of ionic liquids by enhancing sterol content in cell membranes, enabling robust growth in up to 18% [EMIM][OAc].

Harnessing a Novel P450 Fatty Acid Decarboxylase from Macrococcus caseolyticus for Microbial Biosynthesis of Odd Chain Terminal Alkenes

This paper describes the engineering of a microbial pathway using a novel P450 fatty acid decarboxylase to produce odd-chain terminal alkenes from glucose, achieving a 2.8-fold increase in yield through redox system optimization.

Understanding Functional Roles of Native Pentose-Specific Transporters for Activating Dormant Pentose Metabolism in Yarrowia lipolytica

This study identifies native pentose-specific transporters in Yarrowia lipolytica that enhance xylose and arabinose assimilation, revealing a dormant pentose metabolism pathway.

Comprehensive Characterization of Toxicity of Fermentative Metabolites on Microbial Growth

This study evaluates the toxicity of 32 fermentative metabolites on E. coli growth under anaerobic conditions, identifying factors like carbon chain length and hydrophobicity that influence toxicity.