Machine Learning for Prioritization of Thermostabilizing Mutations for G-protein Coupled Receptors
S. Muk, S. Ghosh, S. Achuthan, X. Chen, X. Yao, M. Sandhu, M. C. Griffor, K. F. Fennell, Y. Che, V. Shanmugasundaram, X. Qiu, C. Tate, N. Vaidehi
The paper develops a machine learning framework to predict thermostable mutations for GPCRs, achieving higher success rates than systematic alanine scanning.
bioRxiv · Jul 25, 2019Biophysics