Author

K. F. Fennell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Approach:deep learning· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Y. Che· 2 shared A. B. Vogel· 1 shared A. E. Stewart· 1 shared A. H. Varghese· 1 shared A. Maxwell· 1 shared A. Muik· 1 shared A. S. Anderson· 1 shared A.-M. Dechert Schmidt· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

Y. Che

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Preclinical Characterization of the Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine

K. Modjarrad, Y. Che, W. Chen, H. Wu, C. I. Cadima, A. Muik, M. S. Maddur, K. R. Tompkins, L. T. Martinez, H. Cai, M. Hong, S. Mensah, B. Cumbia, L. Falcao, J. S. Chang, , K. Swanson

The monovalent Omicron XBB.1.5-adapted BNT162b2 mRNA vaccine elicits stronger neutralizing antibody responses against XBB.1.5 and related sublineages than the bivalent Wild Type + Omicron BA.4/5 vaccine.

bioRxiv · Nov 17, 2023Immunology

An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

J. A. Lees, J. M. Dias, F. Rajamohan, J.-P. Fortin, R. O'Connor, J. X. Kong, E. Hughes, E. L. Fisher, J. B. Tuttle, G. Lovett, B. L. Kormos, R. J. Unwalla, L. Zhang, A.-M. Dechert Schmidt, D. Zhou, , S. Han

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

bioRxiv · May 1, 2023 · PreprintBiophysics

Structural basis for Nirmatrelvir in vitro efficacy against SARS-CoV-2 variants

S. E. Greasley, S. Noell, O. Plotnikova, R. A. Ferre, W. Liu, B. Bolanos, K. F. Fennell, J. Nicki, T. Craig, Y. Zhu, A. E. Stewart, C. M. Steppan

This study evaluates nirmatrelvir's in vitro efficacy against SARS-CoV-2 variants, finding it maintains potency against Omicron and other variants.

bioRxiv · Jan 17, 2022Biochemistry

Machine Learning for Prioritization of Thermostabilizing Mutations for G-protein Coupled Receptors

S. Muk, S. Ghosh, S. Achuthan, X. Chen, X. Yao, M. Sandhu, M. C. Griffor, K. F. Fennell, Y. Che, V. Shanmugasundaram, X. Qiu, C. Tate, N. Vaidehi

The paper develops a machine learning framework to predict thermostable mutations for GPCRs, achieving higher success rates than systematic alanine scanning.

bioRxiv · Jul 25, 2019Biophysics