Author

V. Shanmugasundaram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

A. Dubrovskiy· 1 shared A. Local· 1 shared A. Shakya· 1 shared C. E. Schwartz· 1 shared C. Tate· 1 shared G. Rajaraman· 1 shared H. Hu· 1 shared J. Cho· 1 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

A. Dubrovskiy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 19, 2021

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.

S. A. Saenz, A. Local, T. Carr…·J. M. Ellis

The paper develops three RORγt inhibitors that reduce Th17 differentiation and inflammation in vivo and inhibit tumor growth in PDAC organoids.

DOI 10.1101/2021.02.19.431952

mouseproteomics

𝕏 PostBluesky

BiophysicsbioRxivJul 25, 2019

Machine Learning for Prioritization of Thermostabilizing Mutations for G-protein Coupled Receptors

S. Muk, S. Ghosh, S. Achuthan…·N. Vaidehi

The paper develops a machine learning framework to predict thermostable mutations for GPCRs, achieving higher success rates than systematic alanine scanning.

DOI 10.1016/j.bpj.2019.10.023

protein structuremachine learning (classical)

𝕏 PostBluesky

BiophysicsbioRxivDec 7, 2016

Markov modeling reveals novel intracellular modulation of the human TREK-2 selectivity filter

M. P. Harrigan, K. A. McKiernan, V. Shanmugasundaram…·V. S. Pande

The paper uses molecular dynamics simulations and Markov modeling to show that membrane stretch induces a novel 'pinched' state in the TREK-2 channel's selectivity filter, impairing ion conduction.

DOI 10.1038/s41598-017-00256-y

humanstructural biology

𝕏 PostBluesky