A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5
T. Hanke, J. F. Wong, B.-T. Berger, I. Abdi, L. M. Berger, R. Tesch, C. Tredup, A. N. Bullock, S. Mueller, S. Knapp
The paper develops a selective chemical probe, TP-008, for ALK4 and ALK5 kinases and provides a negative control, enabling mechanistic studies of their signaling pathway and disease roles.
bioRxiv · Jan 23, 2020Biochemistry