Author

A. N. Bullock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Knapp· 2 shared A. Chaikuad· 1 shared A. D. Axtman· 1 shared B.-T. Berger· 1 shared C. I. Wells· 1 shared C. Tredup· 1 shared D. Drewry· 1 shared E. R. Lowry· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

S. Knapp

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

H. W. Ong, Y. Liang, W. Richardson, E. R. Lowry, C. I. Wells, X. Chen, M. Silvestre, K. Dempster, J. A. Silvaroli, J. L. Smith, H. Wichterle, N. S. Pabla, S. K. Ultanir, A. N. Bullock, D. Drewry, A. D. Axtman

The paper develops a potent and selective CDKL5/GSK3 chemical probe and demonstrates its neuroprotective effects in human motor neurons under ER stress.

bioRxiv · Feb 9, 2023 · PreprintCell Biology

DFG-1 residue controls inhibitor binding mode and affinity providing a basis for rational design of kinase inhibitor selectivity

M. Schroeder, A. N. Bullock, O. Fedorov, F. Bracher, A. Chaikuad, S. Knapp

The paper identifies DFG-1 residues as a target for designing selective kinase inhibitors with non-canonical binding modes, showing that bulky DFG-1 residues enable selectivity over smaller ones.

bioRxiv · Jul 1, 2020Biochemistry

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5

T. Hanke, J. F. Wong, B.-T. Berger, I. Abdi, L. M. Berger, R. Tesch, C. Tredup, A. N. Bullock, S. Mueller, S. Knapp

The paper develops a selective chemical probe, TP-008, for ALK4 and ALK5 kinases and provides a negative control, enabling mechanistic studies of their signaling pathway and disease roles.

bioRxiv · Jan 23, 2020Biochemistry