Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning
F. Shi, F. de Fatima Silva, D. Liu, H. U. Patel, J. Xu, W. Zhang, C. Turk, M. Kruger, S. Collins
This study identifies SIK3 as a key mediator of β-adrenergic signaling in adipose thermogenesis, showing that its inhibition promotes browning and thermogenic gene expression.
bioRxiv · Oct 27, 2022Physiology