Seeding competent TDP-43 persists in human patient and mouse muscle
E. M. Lynch, S. Pittman, J. Daw, C. Ikenaga, S. Chen, D. D. Dhavale, M. E. Jackrel, Y. M. Ayala, P. Kotzbauer, C. V. Ly, A. Pestronk, T. E. Lloyd, C. C. Weihl
This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.
bioRxiv · Apr 3, 2024Pathology