Author

M. E. Jackrel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:C. elegans· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. J. Bleyer· 1 shared A. Pestronk· 1 shared A. Puri· 1 shared A. Tariq· 1 shared B. G. Johnson· 1 shared C. C. Weihl· 1 shared C. Gu· 1 shared C. Ikenaga· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCell Biology

A. J. Bleyer

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Author profile →

3 papers

Recent·Most cited

Seeding competent TDP-43 persists in human patient and mouse muscle

E. M. Lynch, S. Pittman, J. Daw, C. Ikenaga, S. Chen, D. D. Dhavale, M. E. Jackrel, Y. M. Ayala, P. Kotzbauer, C. V. Ly, A. Pestronk, T. E. Lloyd, C. C. Weihl

This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.

bioRxiv · Apr 3, 2024Pathology

MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy

Y. Kim, C. Li, C. Gu, E. Tycksen, A. Puri, T. A. Pietka, J. Sivapackiam, Y. Fang, K. Kidd, S.-J. Park, B. G. Johnson, S. Kmoch, J. S. Duffield, A. J. Bleyer, M. E. Jackrel, , Y. M. Chen

This study shows that MANF improves autophagy and mitochondrial function in a mouse model of ADTKD-UMOD, offering a potential therapy for proteinopathies.

bioRxiv · Jan 10, 2023 · PreprintCell Biology

Tuning Hsp104 specificity to selectively detoxify alpha-synuclein

K. L. Mack, H. Kim, M. E. Jackrel, J. Lin, J. E. DeNizio, X. Yan, E. Chuang, A. Tariq, R. R. Cupo, L. M. Castellano, K. A. Caldwell, G. A. Caldwell, J. Shorter

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.

bioRxiv · Apr 15, 2020Bioengineering