SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress and autophagic flow
A. Mozzi, M. Oldani, M. E. Forcella, C. Vantaggiato, G. Cappelletti, C. Pontremoli, F. Valenti, D. Forni, M. Biasin, M. Sironi, P. Fusi, R. Cagliani
This study identifies ORF3c as a SARS-CoV-2 protein that disrupts mitochondrial metabolism, increases oxidative stress, and blocks autophagy, potentially contributing to disease progression.
bioRxiv · Oct 4, 2022 · PreprintMicrobiology