Dityrosine cross-links are present in Alzheimer's disease-derived tau oligomers and paired helical filaments (PHF) which promotes the stability of PHF-core tau (297-391) in vitro.
M. Maina, Y. Al-Hilaly, S. Oakley, G. Burra, T. Khanom, L. Biasetti, K. Mengham, K. E. Marshall, C. Harrington, C. Wischik, L. C. Serpell
This study shows dityrosine crosslinks are present in Alzheimer's disease tau oligomers and paired helical filaments, increasing their stability in vitro.
bioRxiv · May 28, 2022Biochemistry