Dynamics of Cas10 Govern Discrimination between Self and Nonself in Type III CRISPR-Cas Immunity
L. Wang, C. Y. Mo, M. R. Wasserman, J. T. Rostol, L. A. Marraffini, S. Liu
The paper uses single-molecule fluorescence microscopy to study Cas10 dynamics in type III CRISPR-Cas systems, revealing conformational changes that distinguish self from nonself RNA.
bioRxiv · Jul 20, 2018Biophysics