Author

J. T. Rostol

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:biophysical modeling· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Berk· 2 shared C. Garcia-Doval· 2 shared F. Schwede· 2 shared J. Hall· 2 shared L. A. Marraffini· 2 shared M. Jinek· 2 shared O. Niewoehner· 2 shared C. Y. Mo· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

C. Berk

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

C. Garcia-Doval, F. Schwede, C. Berk, J. T. Rostol, O. Niewoehner, O. Tejero, J. Hall, L. A. Marraffini, M. Jinek

This study investigates how EiCsm6 degrades its activator cA6 and uses structural and functional analyses to reveal activation and self-inactivation mechanisms of the CRISPR ribonuclease.

bioRxiv · Feb 19, 2020Biochemistry

Dynamics of Cas10 Govern Discrimination between Self and Nonself in Type III CRISPR-Cas Immunity

L. Wang, C. Y. Mo, M. R. Wasserman, J. T. Rostol, L. A. Marraffini, S. Liu

The paper uses single-molecule fluorescence microscopy to study Cas10 dynamics in type III CRISPR-Cas systems, revealing conformational changes that distinguish self from nonself RNA.

bioRxiv · Jul 20, 2018Biophysics

Type III CRISPR-Cas systems generate cyclic oligoadenylate second messengers to activate Csm6 RNases

O. Niewoehner, C. Garcia-Doval, J. T. Rostol, C. Berk, F. Schwede, L. Bigler, J. Hall, L. Marraffini, M. Jinek

bioRxiv · Jun 23, 2017Biochemistry