Multi-region exome sequencing of ovarian teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components
M. B. Heskett, J. Z. Sanborn, C. Boniface, B. Goode, J. Chapman, K. Garg, J. T. Rabban, C. Zaloudek, S. C. Benz, P. T. Spellman, D. A. Solomon, R. J. Cho
This study uses multi-region exome sequencing to show ovarian immature teratomas have near-diploid genomes, extensive allelic imbalances, and clonal origins across different tumor components.
bioRxiv · Oct 28, 2019Cancer Biology