Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
C. Ak, Z. Sayar, G. Thibault, E. Burlingame, J. Eng, A. Chitsazan, A. Adey, C. Boniface, P. T. Spellman, G. V. Thomas, R. Kopp, E. Demir, Y. H. Chang, V. Stavrinides, S. E. Eksi
bioRxiv · Aug 18, 2023 · PreprintCancer Biology
B. Gurun, J. W. Tyner, E. Demir, B. J. Druker, P. T. Spellman
This paper uses supervised and unsupervised models to identify new methylation pathways and improve AML risk-stratification by analyzing epigenetic changes in progenitor cells.
bioRxiv · May 17, 2023 · PreprintCancer Biology
S. E. Eksi, A. Chitsazan, Z. Sayar, A. Fields, R. Kopp, G. V. Thomas, P. T. Spellman, A. Adey
This study uses single-cell chromatin accessibility analysis to identify distinct gene regulatory programs in low- and high-grade prostate cancers, revealing shared transcription factor binding sites and novel neuronal adhesion molecules.
bioRxiv · Apr 16, 2021 · PreprintCancer Biology
S. C. Dentro, I. Leshchiner, K. Haase, M. Tarabichi, J. Wintersinger, A. G. Deshwar, K. Yu, Y. Rubanova, G. Macintyre, J. Demeulemeester, I. Vazquez-Garcia, K. Kleinheinz, D. G. Livitz, S. Malikic, N. Donmez, , Q. D. Morris
This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.
Cell · Apr 1, 2021Peer-reviewedCancer Biology
B. E. Johnson, A. L. Creason, J. M. Stommel, J. M. Keck, S. Parmar, C. B. Betts, A. Blucher, C. Boniface, E. Bucher, E. A. Burlingame, T. Camp, K. Chin, J. Eng, J. Estabrook, H. S. Feiler, , J. W. Gray
This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.
bioRxiv · Dec 3, 2020Cancer Biology
S. Naffar-Abu Amara, H. J. Kuiken, L. M. Selfors, T. Butler, M. L. Leung, C. T. Leung, E. P. Kuhn, T. R. Kolarova, C. Hage, K. Ganesh, R. Foster, B. R. Rueda, A. Aktipis, P. T. Spellman, T. Ince, , J. S. S. Brugge
The paper shows that transient interactions between non-tumorigenic and tumorigenic clones can drive metastasis through amphiregulin-mediated mesothelial clearance.
bioRxiv · Jan 16, 2020 · PreprintCancer Biology
M. B. Heskett, J. Z. Sanborn, C. Boniface, B. Goode, J. Chapman, K. Garg, J. T. Rabban, C. Zaloudek, S. C. Benz, P. T. Spellman, D. A. Solomon, R. J. Cho
This study uses multi-region exome sequencing to show ovarian immature teratomas have near-diploid genomes, extensive allelic imbalances, and clonal origins across different tumor components.
bioRxiv · Oct 28, 2019Cancer Biology
M. Tarabichi, I. Martincorena, M. Gerstung, A. M. Leroi, F. Markowetz, P. T. Spellman, Q. D. Morris, O. C. Lingjaerde, D. C. Wedge, P. Van Loo, PCAWG Evolution and Heterogeneity Working Group
The paper explores tumor evolution through subclonal analysis and discusses the role of driver and passenger mutations in cancer progression.
bioRxiv · Jul 23, 2018Cancer Biology