A systematic analysis of rodent models implicates adipogenesis and innate immunity in pathogenesis of fatty liver disease
Y. R. Im, H. Hunter, D. de Gracia Hahn, A. Duret, Q. Cheah, J. Dong, M. Fairey, C. Hjalmarsson, A. Li, H. K. Lim, L. McKeown, C.-G. Mitrofan, R. Rao, M. Utukuri, I. A. Rowe, J. P. Mann
This study analyzes 3,920 rodent models of NAFLD, finding adipose dysfunction and innate immune perturbation are key factors, and high-fat, high-fructose diets best mimic human NAFLD.
bioRxiv · Dec 15, 2020 · PreprintPhysiology