R. Rao

Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

This study shows that inhibiting the UFD-1-NPL-4 complex in C. elegans triggers an aberrant immune response that harms immunocompetent worms but benefits immunocompromised ones.

The Endosomal pH Regulator NHE6 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes

This study shows that NHE6 is essential for insulin-stimulated glucose uptake in adipocytes by regulating GLUT4 trafficking and expression.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes

This paper introduces a novel flexible adhesive electrode array for non-invasive cervical nerve activity monitoring and demonstrates its use in detecting stress-induced neuronal changes.

Evolutionary Dynamics, Evolutionary Forces, and Robustness: A Nonequilibrium Statistical Mechanics Perspective

The paper introduces a non-equilibrium thermodynamic model of evolutionary dynamics, identifying a new phenomenon called enaptation that arises without explicit selection.

The Endosomal pH Regulator NHE9 is a Driver of Stemness in Glioblastoma

This paper identifies NHE9 as a driver of stemness in glioblastoma by showing it increases receptor tyrosine kinase stability and activates JAK2-STAT3 to induce pluripotency genes.

SLIT2-ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia

This study shows that SLIT2-ROBO signaling in tumor-associated microglia/macrophages promotes glioblastoma immunosuppression and vascular dysmorphia, and its inhibition reduces tumor growth and enhances therapy.

A systematic analysis of rodent models implicates adipogenesis and innate immunity in pathogenesis of fatty liver disease

This study analyzes 3,920 rodent models of NAFLD, finding adipose dysfunction and innate immune perturbation are key factors, and high-fat, high-fructose diets best mimic human NAFLD.

Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells

This study shows that histone deacetylase inhibitors increase SPCA2 levels, activate Ca2+ signaling, and reverse epithelial to mesenchymal transition in triple receptor negative breast cancer cells.

Store Independent Ca2+ Entry Regulates the DNA Damage Response in Breast Cancer Cells

This study identifies SPCA2 as a driver of chemotherapy resistance in ER+/p53WT breast cancer by suppressing the DNA damage response through store-independent Ca2+ entry.

What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression.

This paper meta-analyzes rodent studies on NAFLD treatments, finding limited efficacy and high bias, suggesting challenges in translating animal results to human therapies.

A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells

This study identifies SPCA2 as a regulator of E-cadherin biogenesis and epithelial-mesenchymal transition in breast cancer, independent of its Ca2+ pump activity.

NHA2 promotes cyst development in an in vitro model of polycystic kidney disease

This study identifies NHA2 as a regulator of cyst development in ADPKD by showing its up-regulation correlates with disease severity and its causal role in increased cyst size in vitro.