Combinatorial effect of miR-486-5p & miR-22-3p mimics thrombopoietin's impact on hematopoietic stem & progenitor cells
C.-Y. Kao, J. Jiang, E. T. PAPOUTSAKIS
The paper identifies miR-486-5p and miR-22-3p as drivers of megakaryocytic differentiation in HSPCs without thrombopoietin, and shows MkMPs induce this through JNK and PI3K/Akt/mTOR signaling.
bioRxiv · Feb 9, 2020 · PreprintCell Biology