Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons
Kirsten G. Bredvik, C.C. Liu, Timothy A. Ryan
This study shows that β-hydroxybutyrate supports neurotransmission in both excitatory and inhibitory neurons through cell-autonomous mitochondrial metabolism, with differential ATP levels and kinetics compared to lactate/pyruvate.
bioRxiv · Jun 8, 2024 · PreprintNeuroscience