Kirsten G. Bredvik

The paper develops a ratiometric ER calcium sensor to enable quantitative comparisons of ER Ca2+ levels across cell types and subcellular regions, showing lower resting Ca2+ in neurons compared to fibroblasts.

This study shows that β-hydroxybutyrate supports neurotransmission in both excitatory and inhibitory neurons through cell-autonomous mitochondrial metabolism, with differential ATP levels and kinetics compared to lactate/pyruvate.

The paper identifies differences in mitochondrial function between inhibitory and excitatory neurons, showing inhibitory terminals have higher ATP levels and distinct Ca2+ handling mechanisms.

The paper uses machine learning on fibroblast morphometry to predict stress but finds limited ability to distinguish ALS from controls.

The paper identifies a subclass of sporadic ALS patients with metabolic defects in trans-sulfuration, characterized by increased cysteine and glutathione synthesis and distinct metabolic responses.

The paper identifies a distinct metabolomic subtype in sporadic ALS patients through metabolite profiling and multi-omics integration, showing increased cysteine metabolism and potential therapeutic targets.