Bivalent ligands as a new universal chemotype of BCL6 degrader by inducing aggregation
Rong Hu, Xia-Tong Hu, Ying-Yue Yang, Peng Luo, Caihua Li, Zhihao Liu, Luoting Yu, Ningyu Wang
This paper introduces bivalent ligands (HBiDs) that degrade BCL6 by inducing dimer aggregation and ubiquitination, showing high selectivity and potential as drug candidates.
bioRxiv · Feb 25, 2025 · PreprintBiochemistry