Rong Hu

Chromosomal instability increases radiation sensitivity

The paper shows that higher chromosomal instability (CIN) in cancer cells and tumors increases sensitivity to radiation, both directly and through drug-induced CIN mechanisms.

Mycobacterium tuberculosis, Mycobacterium kansasii and Rhodococcus equi induce macrophage necroptosis in the presence of a caspase inhibitor acting on a non-canonical target(s)

This study shows that z-VAD induces necroptosis in macrophages infected with Mtb, M. kansasii, and R. equi by acting on non-canonical targets, and MLKL deficiency reduces TB pathology in susceptible mice.

Bivalent ligands as a new universal chemotype of BCL6 degrader by inducing aggregation

This paper introduces bivalent ligands (HBiDs) that degrade BCL6 by inducing dimer aggregation and ubiquitination, showing high selectivity and potential as drug candidates.