Assessing bnAb potency in the context of HIV-1 Envelope conformational plasticity
Caio Foulkes, Nikolas Friedrich, Branislav Ivan, Emanuel Stiegeler, Carsten Magnus, Daniel G. Schmidt, Umut Karakus, Jacqueline Weber, Huldrych F. Günthard, Chloé Pasin, Peter Rusert, Alexandra Trkola
This study assesses how HIV-1 broadly neutralizing antibodies (bnAbs) respond to Env conformational changes by screening mutants, revealing variation in potency based on epitope and Env flexibility.
PLoS Pathogens · Jan 21, 2025Peer-reviewedImmunology