ThermoClock: A Novel Automated Temperature Regulation Device that Can Model Circadian Entrainment and Disruption in 2D and 3D in Vitro Models
Kaiyin Kelly Zhang, Cathryn A. Cutia, Chanelle A. Moise, Bhavna Kalyanaraman, Caitlin Chee, Jiexin Jennifer Wang, Michelle E. Farkas, Ilia N. Karatsoreos, Mary E. Harrington, Meghan E. Huber, Cathal John Kearney
ThermoClock is an automated temperature control system that models circadian entrainment and disruption in 2D and 3D in vitro models, showing that ramp time and cycle duration affect rhythm strength and wound healing.
bioRxiv · Jul 31, 2026 · PreprintBioengineering