RNase H1 levels dramatically affect mitochondrial genome maintenance with little impact on nuclear R-loops in murine B cells
Kiran Sakhuja, Stella R. Hartono, Lionel A. Sanz, Eriko Ijiri, Caitlin L. Darling, Louis Dye, James Iben, Hyongi Chon, Susana M. Cerritelli, Robert J. Crouch, Frederic L. Chedin
This study shows that RNase H1 is critical for mitochondrial genome maintenance in B cells but has little effect on nuclear R-loops.
bioRxiv · Apr 30, 2025 · PreprintGenomics