James Iben

This study identifies the developmental origin and regulation of best4+ intestinal cells in zebrafish and demonstrates their functional roles and limitations.

This study identifies and characterizes specialized endothelial cells in zebrafish gills that resemble mammalian lung aerocytes, using single-cell RNA sequencing and advanced imaging techniques.

This study shows that RNase H1 is critical for mitochondrial genome maintenance in B cells but has little effect on nuclear R-loops.

The paper introduces an EpiTag zebrafish transgenic reporter to visualize epigenetic silencing/activation and identifies tissue-specific epigenetic regulatory genes through mutagenesis screening.

This paper characterizes the zebrafish meninges using single-cell transcriptomics, identifying a novel cell type essential for brain development.

The paper identifies a new external immune organ in zebrafish, the axillary lymphoid organ, suitable for live imaging of immune cell dynamics.

This study shows that Pab1 in yeast primarily controls translation by blocking mRNA decapping and decay, with reduced mRNA abundance driving translational changes.

The paper identifies tendon-associated gene expression as a key factor in mid-palatal suture establishment and shows similarities with cranial suture biology.

The paper identifies a POLR3B variant causing mis-splicing and altered Pol III transcriptome, revealing La protein's role in reshaping small ncRNA profiles and identifying tRF-1/tRF-3 as biomarkers for POLR3 deficiency.

This study investigates the role of Dkk2 in palatogenesis using Pax9-/- mouse models and spatial multiomics data, revealing its spatial relationship with osteogenic populations.

The paper uses integrated bulk, single-cell, and spatial RNA-seq to uncover the timeline of osteogenic transcriptional programming in embryonic palate development, identifying novel genes and spatial expression patterns involved in palatal fusion.

The paper presents a fully automated FAIMS-DIA proteomic pipeline for iPSC-derived neurons, showing high protein identification and reproducibility, validated against single-cell RNA-Seq data.

The paper introduces TIARS, a method to detect precise CRISPR/Cas9 edits using restriction-fragment length polymorphisms, and validates it in zebrafish for atp7a gene mutations.

This study investigates the in vivo roles of RHOA in vascular development and integrity using zebrafish models, finding that both gain- and loss-of-function lead to vascular dysfunction.