Unexpected ribosome turnover during prolonged translation inhibition
Paul J. Russell, Caleb A. Clark, Mia Ashriem, Michael G. Kearse
This study shows that prolonged translation inhibition by cycloheximide causes proteasome-dependent degradation of ribosomal RNA and proteins, revealing a new quality control pathway called GRIP.
bioRxiv · Oct 5, 2026 · PreprintMolecular Biology