Single molecule studies of the bacterial curli protein CsgA reveal a structurally dynamic monomeric structure
Daniel A. N. Foster, Kirill Kudriavtsev, Calum Ryan Byrne, Simcha Srebnik, Derek R. Dee
This study uses single-molecule force spectroscopy to reveal that CsgA exists in metastable folded states and disordered states, which are aggregation-prone and previously uncharacterized at the ensemble level.
bioRxiv · Sep 8, 2025 · PreprintBiophysics