Simcha Srebnik

This paper develops a coarse-grained model for simulating nascent polypeptide dynamics in the ribosome, enabling efficient simulation of elongation and escape processes.

This study uses single-molecule force spectroscopy to reveal that CsgA exists in metastable folded states and disordered states, which are aggregation-prone and previously uncharacterized at the ensemble level.

The paper identifies prokaryotic-like ribosome exit tunnels in eukaryotic protists by analyzing structural and sequence data from 725 ribosome models.