GSK3 inhibition ameliorates the abnormal contractility of Newfoundland ACM patient iPSC-cardiomyocytes
Rebecca J. Noort, Wesam Salman, Camila Fuchs, Ursula Braun, David Pace, Kathleen A. Hodgkinson, Jessica L. Esseltine
This study investigates the effects of GSK3 inhibition on cardiomyocytes from Newfoundland ACM patients with a TMEM43 p.S358L mutation, finding it improves contractility and reduces arrhythmogenic tendencies.
bioRxiv · Feb 6, 2024Cell Biology