Cell BiologybioRxiv
GSK3 inhibition ameliorates the abnormal contractility of Newfoundland ACM patient iPSC-cardiomyocytes
Rebecca J. Noort, Wesam Salman, Camila Fuchs…·Jessica L. Esseltine
This study investigates the effects of GSK3 inhibition on cardiomyocytes from Newfoundland ACM patients with a TMEM43 p.S358L mutation, finding it improves contractility and reduces arrhythmogenic tendencies.