Author

Jessica L. Esseltine

Memorial University of NewfoundlandORCID 0000-0002-0770-2334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Rebecca J. NoortiD· 2 shared Camila Fuchs· 1 shared Craig Stephen MooreiD· 1 shared David Pace· 1 shared Hanrui Zhu· 1 shared Kathleen A. HodgkinsoniD· 1 shared Robert T. Flemmer· 1 shared Thomas James BelbiniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Rebecca J. NoortORCID

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2 papers

Recent·Most cited

GSK3 inhibition ameliorates the abnormal contractility of Newfoundland ACM patient iPSC-cardiomyocytes

Rebecca J. Noort, Wesam Salman, Camila Fuchs, Ursula Braun, David Pace, Kathleen A. Hodgkinson, Jessica L. Esseltine

This study investigates the effects of GSK3 inhibition on cardiomyocytes from Newfoundland ACM patients with a TMEM43 p.S358L mutation, finding it improves contractility and reduces arrhythmogenic tendencies.

bioRxiv · Feb 6, 2024Cell Biology

Apically localized PANX1 impacts neuroepithelial expansion in human cerebral organoids

Rebecca J. Noort, Hanrui Zhu, Robert T. Flemmer, Craig Stephen Moore, Thomas James Belbin, Jessica L. Esseltine

This study shows PANX1 is dynamically expressed during human brain development and its loss reduces neuroepithelial expansion by disrupting adhesion, signaling, and gene regulation.

Cell Death Discovery · Jan 11, 2024Peer-reviewedNeuroscience