Huntingtin is a cell-autonomous regulator of neuropeptide trafficking and clock output
Agustina Bruno-Vignolo, Cayetana Arnaiz, Florencia Fernández-Chiappe, Ana Ricciuti, Lautaro Alejandro Duarte, Ivana Ducrey, Ivana Marcela Linenberg, Cora Pollak, Pedro Lorenzo Ballestero, Marina Propato-Lots, Camila Sofia Falzone, Esteban J. Beckwith, Tomás Luis Falzone, Nara Ines Muraro
This study shows that wild-type Huntingtin regulates neuropeptide trafficking, neuronal excitability, and circadian rhythms in Drosophila, with loss of function causing sleep disturbances and disrupted vesicle dynamics.
bioRxiv · Jul 26, 2026 · PreprintNeuroscience