Tomás Luis Falzone

Tau isoforms modulate the axon initial segment controlling axonal trafficking and neuronal excitability

This study shows that tau isoform balance regulates axon initial segment maturation, excitability, and transport, linking cytoskeletal organization to neuronal function.

Huntingtin is a cell-autonomous regulator of neuropeptide trafficking and clock output

This study shows that wild-type Huntingtin regulates neuropeptide trafficking, neuronal excitability, and circadian rhythms in Drosophila, with loss of function causing sleep disturbances and disrupted vesicle dynamics.

DYRK1A role in microtubule-based axonal transport regulates the retrograde dynamics of APP vesicles in human neurons

This study investigates how DYRK1A affects APP vesicle transport in human neurons, finding that its inhibition reduces retrograde transport while overexpression increases it.