Multiparametric Signature of Glioblastoma Differentiation Revealed by Imaging of Cellular Epigenetic Landscapes
Chen Farhy, Santosh Hariharan, Jarkko Ylanko, Lotte van Woudenberg, Flavio Cimadamore, Fernando Ugarte, Camilla Forsberg, Chun-Teng Huang, David W. Andrews, Alexey V. Terskikh
The paper develops MIEL, an imaging method to identify epigenetic signatures of differentiated glioblastoma cells and validates its use in selecting small molecules that induce tumor-propagating cell differentiation.
bioRxiv · Aug 16, 2018 · PreprintCancer Biology