Alexey V. Terskikh

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.

This study shows that aging alters macrophage phenotypes in the melanoma microenvironment, with TREM1 and TREM2 playing distinct roles in tumor progression and metastasis in aged mice.

The paper introduces ImAge, an image-based biomarker of aging and rejuvenation using chromatin and epigenetic patterns, showing correlation with chronological age and response to interventions.

The paper develops MIEL, an imaging method to identify epigenetic signatures of differentiated glioblastoma cells and validates its use in selecting small molecules that induce tumor-propagating cell differentiation.

The paper models gene expression networks to predict interchromosomal organization during human embryonic stem cell differentiation and finds that coordinate gene regulation correlates with 3D chromosome organization.