Chen Farhy

The paper introduces ImAge, an image-based biomarker of aging and rejuvenation using chromatin and epigenetic patterns, showing correlation with chronological age and response to interventions.

The paper identifies astrocyte synapse-regulating genes in the developing mouse visual cortex and shows their expression is modulated by neuronal activity and calcium signaling.

The paper develops MIEL, an imaging method to identify epigenetic signatures of differentiated glioblastoma cells and validates its use in selecting small molecules that induce tumor-propagating cell differentiation.