BRUCE liver-deficiency potentiates MASLD/MASH in PTEN liver-deficient background by impairment of mitochondrial metabolism in hepatocytes and activation of STAT3 signaling in hepatic stellate cells
Lixiao Che, Camille K. Stevenson, David R. Plas, Jiang Wang, Chunying Du
The paper shows BRUCE and PTEN together suppress MASLD/MASH by maintaining mitochondrial metabolism and preventing STAT3 activation in HSCs, with DKO mice showing severe liver disease.
bioRxiv · Sep 13, 2024 · PreprintMolecular Biology