David R. Plas

This study identifies CPI203, a BET inhibitor, as a compound that consistently down-regulates DNA synthesis genes across multiple glioblastoma lines.

This study shows copper drives metabolic remodeling and progression in clear cell renal cell carcinoma by coordinating bioenergy, biosynthesis, and redox homeostasis.

The paper shows BRUCE and PTEN together suppress MASLD/MASH by maintaining mitochondrial metabolism and preventing STAT3 activation in HSCs, with DKO mice showing severe liver disease.

The paper develops a framework to predict signaling pathway activity changes by integrating genetic perturbation data across cell lines, improving prediction accuracy using multi-task learning and supervised methods.

The paper develops a method to predict the mechanism of action of cellular perturbations by analyzing pathway network topology and transcriptional signatures.