CBP/EP300 acetylates and stabilizes the stress-responsive Heat Shock Factor 2, a process compromised in Rubinstein-Taybi syndrome
Aurélie de Thonel, Johanna K. Ahlskog, Kévin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón-Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, , Valérie Mezger
The paper shows that CBP/EP300 acetylates and stabilizes HSF2, which is disrupted in Rubinstein-Taybi syndrome, leading to impaired heat shock response.
Nature Communications · Nov 16, 2022Peer-reviewedDevelopmental Biology