Anniina Vihervaara

The paper identifies a co-dependency between CDK12 and the BAF chromatin-remodeling complex in TNBC, showing that their co-inhibition synergistically reduces cancer cell viability.

The paper examines transcriptional responses to different proteotoxic stressors and identifies tissue-specific adaptations in Huntington's Disease mice.

The paper characterizes transcriptional architectures and Pol II regulation in dog cells, revealing promoter, enhancer, and enhancer cluster structures and their response to heat stress.

The paper tracks transcription during erythroid differentiation and identifies NRF2's role in initiating an antioxidant program without oxidative stress.

The paper shows CCG-1423-derived compounds inhibit hsp gene transcription in fly and mammalian cells by reducing RNA polymerase II elongation and dampening heat shock responses.

This study uses PRO-seq to profile nascent transcription in Aedes aegypti, identifying regulatory elements and dynamic immune responses to bacterial stimulation.

The paper introduces PRO-IP-seq to track Pol II CTD phosphorylation at nucleotide resolution and reveals its dynamic regulation during transcription.

The paper shows that CBP/EP300 acetylates and stabilizes HSF2, which is disrupted in Rubinstein-Taybi syndrome, leading to impaired heat shock response.

The paper provides analytical steps to identify regulatory elements and quantify transcription complexes using nascent RNA-sequencing data in human cells.

This study shows HSF1 and HSF2 regulate gene and enhancer transcription differently under oxidative stress and heat shock by controlling RNA polymerase II pause-release.

This study shows that chromatin conformation remains stable during heat shock-induced transcriptional changes in human and Drosophila cells.

This study shows that heat shock induces transcriptional memory in cells, accelerating promoter-proximal pause-release and slowing termination over mitotic divisions.