Geoffrey Pires

Compilation of all known protein changes in the human Alzheimer's disease brain

The paper compiles and analyzes proteomic data from 38 Alzheimer's disease studies to create a database of protein changes in human brain tissue across disease stages and regions, revealing patterns of protein dysfunction.

CBP/EP300 acetylates and stabilizes the stress-responsive Heat Shock Factor 2, a process compromised in Rubinstein-Taybi syndrome

The paper shows that CBP/EP300 acetylates and stabilizes HSF2, which is disrupted in Rubinstein-Taybi syndrome, leading to impaired heat shock response.

Proteomic Differences in the Hippocampus and Cortex of Epilepsy Brain Tissue

The paper identifies proteomic differences in epilepsy brain tissue, highlighting altered protein networks in hippocampus, cortex, and dentate gyrus, with GNB1 as a key decreased protein.

Proteomic and Transcriptomic Analyses of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Cases

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.